Sejo se eketsang lijo: Tributyrin

Dikahare: 95%, 90%

Tributyrin e le sejo se tlatsetsang ho ntlafatsa bophelo bo botle ba mala a likhoho.

Ho kgaotsa ho sebedisa dithibela-mafu e le di-promoter tsa kgolo ho tswa diresepeng tsa dijo tsa dikgoho ho ekeditse thahasello ya maano a mang a phepo, bakeng sa ho eketsa tshebetso ya dikgoho hammoho le ho di sireletsa kgahlanong le mathata a bakwang ke mafu.

Ho fokotsa bohloko ba dysbacteriosis
E le ho hlahloba maemo a dysbacteriosis, ho eketsoa lijo tse ling tse kang li-probiotic le li-prebiotic ho susumetsa tlhahiso ea li-SCFA, haholo-holo asiti ea butyric e bapalang karolo ea bohlokoa ho sireletseng botšepehi ba mala. Asiti ea butyric ke SCFA e hlahang ka tlhaho e nang le litlamorao tse ngata tse fapaneng tse kang phello ea eona ea ho thibela ho ruruha, tšusumetso ea eona ea ho potlakisa ts'ebetso ea ho lokisa mala le ho susumetsa nts'etsopele ea li-gut villi. Ho na le tsela e ikhethang eo asiti ea butyric e sebetsang ka eona ka mokhoa oa ho thibela tšoaetso, e leng tlhahiso ea Host Defense Peptides (HDPs), e tsejoang hape e le li-peptide tse khahlanong le likokoana-hloko, e leng likarolo tsa bohlokoa tsa tšireletso ea tlhaho ea 'mele. Li na le ts'ebetso e kholo ea ho loantša likokoana-hloko khahlanong le libaktheria, li-fungus, likokoana-hloko le livaerase tse koahetsoeng tse thata haholo hore likokoana-hloko li holise khanyetso khahlanong le tsona. Li-Defensins (AvBD9 & AvBD14) le Cathelicidins ke malapa a mabeli a maholo a HDP (Goitsuka et al.; Lynn et al.; Ganz et al.) tse fumanoang likhoho tse matlafatsoang ke tlatsetso ea asiti ea butyric. Phuputsong e entsoeng ke Sunkara et. al. Tsamaiso ea kantle ea asiti ea butyric e baka keketseho e makatsang ea tlhahiso ea liphatsa tsa lefutso tsa HDP 'me ka hona e eketsa bokhoni ba ho hanyetsa mafu likhoho. Hoa thahasellisa hore, e itekanetseng le LCFAs li ka tlase.

Melemo ea bophelo bo botle ea Tributyrin
Tributyrin ke selelekela sa asiti ea butyric e lumellang limolek'hule tse ngata tsa asiti ea butyric ho kenngoa ka maleng a manyane ka kotloloho ka lebaka la mokhoa oa ho esterification. Ka hona, mahloriso a phahame habeli ho isa ho a mararo ho feta lihlahisoa tse tloaelehileng tse koahetsoeng. Esterification e lumella limolek'hule tse tharo tsa asiti ea butyric ho tlamahana le glycerol e ka robehang feela ke pancreatic lipase ea tlhaho.
Li et al. ba thehile phuputso ea immunological ho fumana liphello tse molemo tsa tributyrin ho li-cytokine tse hlahisang ho ruruha ho li-broiler tse nang le bothata ba LPS (lipopolysaccharide). Tšebeliso ea LPS e tsebahala haholo ho baka ho ruruha lithutong tse kang ena kaha e kenya tšebetsong matšoao a ho ruruha a kang IL (Interleukins). Matsatsing a 22, 24, le 26 a teko, li-broiler li ile tsa phephetsoa ka tsamaiso ea 500 μg/kg BW LPS kapa saline ka hare ho peritoneal. Tlatsetso ea tributyrin ea lijo ea 500 mg/kg e ile ea thibela keketseho ea IL-1β le IL-6 e bontšang hore tlatsetso ea eona e khona ho fokotsa ho lokolloa ha li-cytokine tse hlahisang ho ruruha 'me ka hona ea fokotsa ho ruruha ha mala.

Kakaretso
Ka tšebeliso e thibetsoeng kapa thibelo e felletseng ea li-promoter tse itseng tsa kholo ea lithibela-mafu e le li-additives tsa lijo, maano a macha a ho ntlafatsa le ho sireletsa bophelo bo botle ba liphoofolo tsa polasing a tlameha ho hlahlojoa. Botšepehi ba mala bo sebetsa e le sebopeho sa bohlokoa pakeng tsa lisebelisoa tse tala tsa lijo tse turang le ho khothaletsa kholo ho likhoho tsa nama. Asiti ea butyric haholo-holo e tsejoa e le mohloli o matla oa bophelo bo botle ba mala o seng o ntse o sebelisoa lijong tsa liphoofolo ka lilemo tse fetang 20. Tributyrind e fana ka asiti ea butyric ka maleng a manyane 'me e sebetsa haholo ho ama bophelo bo botle ba mala ka ho potlakisa ts'ebetso ea ho lokisa mala, e khothaletsa nts'etsopele e ntle ea villi le ho fetola karabelo ea' mele ea ho itšireletsa mafung ka har'a mala.

Jwale kaha dithibela-mafu di ntse di fediswa, asiti ya butyric ke sesebediswa se seholo sa ho tshehetsa indasteri ho fokotsa tshusumetso e mpe ya dysbacteriosis e hlahellang ka lebaka la phetoho ena.