Mekhoa e meng ea phekolo ea lithibela-mafu e ea hlokahala ka lebaka la thibelo ea tšebeliso ea meriana ena e le ba khothalletsang kholo tlhahisong ea lijo tsa liphoofolo. Tributyrin e bonahala e phetha karolo ea ho ntlafatsa ts'ebetso ea kholo ea likolobe, le hoja e na le litekanyetso tse fapaneng tsa katleho.

Ho fihlela joale, ha ho tsejoe haholo ka litlamorao tsa eona ho sebopeho sa gut microbiota. Thutong ena, re ile ra etsa lipatlisiso ka liphetoho tsa mala a microbiota a likolobe tse amohelang, ha li khoesoa, 0.2% tributyrin e kenyellelitsoe lijong tsa bona tsa basal.

Sehlopha sa Tributyrin se na le monyetla o matlafalitsoeng oa metabolism ea matla le monyetla o fokotsehileng oa metabolism ea carbohydrate. Qetellong, liphetho tsa rona li bonts'itse hore tributyrin e ka khothaletsa liphetoho sechabeng sa likokoana-hloko tsa mala, tse ka kenyang letsoho ho ntlafatseng ts'ebetso ea liphoofolo ka mor'a ho khoesoa.

Litlamorao tsa Tributyrin ho Gut Microbiota Shifts e Amanang le Ts'ebetso ea Likolobe tse Amisoang.

Lihlahisoa tsa lihlahisoa

Tributyrin (hape e bitsoa Glyceryl tributyrate; Glycerol tributyrate; Glycery tributyrate; propane-1,2,3-triyl tributanoate), ke mofuta oa ketane e khutšoane ea mafura a acid ester.

CAS RN: 60-01-5

Nomoro ea EINECS: 200-451-5

Mokhoa: C15H26O6

FW: 302.36

Ponahalo: Ke mokelikeli o mafura o mosoeu ho isa ho o mosehla o nang le monko o mafura hanyane.

Sollubility: e qhibilihang ka har'a ethanol, chloroform le ether, ha e khone ho qhibiliha ka metsing (0.010%).

Shelf Life: Likhoeli tse 24

Pakete: 25KG / Mokotla

Polokelo: E koaletsoe libakeng tse omeletseng le tse nang le moea o kenang

Tributyrinke triglyceride e nang le limolek'hule tse tharo tsa butyrate esterified ho glycerol, e eketsa bongata ba butyrate ka mor'a hydrolyzation ka pancreatic lipases.

Litšobotsi tsa Tributyrin
Moloko o mocha oa butyrate-glycerol ester ea butyric acid.
100% bypass mala.
Ho fana ka li-butyric acid ka maleng a manyane, ha ho hlokahale hore li koaheloe.
Ka tlhaho e fumaneha lebeseng le maheng a linotsi.

Papiso Pakeng tsa Tributyrin & Butyrate Letsoai

halofo ea bophelo ba asiti ea butyric ke metsotso e 6. Butyrate e thata ho fihlella lisele tse ling le litho tse ling tse ka ntle ho mala a tsamaisoang ka mokhoa oa butyric acid kapa butyrate.Leha ho le joalo halofo ea bophelo ea tributyrin ke 40min, 'me motsoako oa plasma oa butyrate o ka bolokoa ka holimo ho 0.1mM bakeng sa 0.5-4h ka molomo.

Mokhoa le Likarolo

Mofani oa Matla

Joalo ka ha ho tsebahala, asiti ea butyric ke acid e khuts'oane ea mafura eo e leng mohloli o ka sehloohong oa matla a lisele tsa epithelial tsa mala. Ho feta 70% ea matla bakeng sa kholo ea lisele tsa mala a epithelial a fanoa ke asiti ea butyric. Leha ho le joalo, tributyrin e fana ka boleng bo phahameng ka ho fetesisa bo lokollang butyric acid ha bo bapisoa le lihlahisoa tse ling tsa butyrate.

Tšireletso ea mala

►Tributyrin e khothalletsa ho ata le ho arohana ha lisele tsa mala a mala, ho lokisa mucosa e senyehileng, le ho atolosa sebaka se ka holimo bakeng sa ho monya limatlafatsi.

►Tributyrin e khothalletsa polelo ea liprotheine tse thata ka maleng, e boloka likamano tse thata pakeng tsa lisele, e thibela li-macromolecules tse kang libaktheria le chefo hore li se ke tsa kena 'meleng,' me li boloka mosebetsi oa thibelo ea 'mele oa mala.

►Tributyrin e khothalletsa tlhahiso ea mucin (Muc) le ho matlafatsa ts'ebetso ea thibelo ea lik'hemik'hale tsa mala.

Sekhahla sa ho Pholoha se Ntlafetse

Tributyrin e ka khothaletsa motsoako oa hemoglobin, ea ntlafatsa bokhoni ba ho tsamaisa oksijene, ea matlafatsa ts'ebetso ea ts'ehetso ea bophelo, hape e ka ntlafatsa ts'ebetso ea mitochondria le ho khothaletsa motsoako oa ATP, ntho ea matla e tsamaisang ts'ebetso ea bophelo. joalo ka ho ntlafatsa sekhahla sa ho phela kapa liphoofolo.

Anti-Inflammatory & Antibacterial

►Ka ho thibela mosebetsi oa NF-Kb, TNF-α le TLR, Tributyrin e ka fokotsa tšenyo ea ho ruruha.

►Tributyrin e khothalletsa polelo ea li-peptide tsa ts'ireletso tsa endogenous, tse ka hanyetsang pathogen le kokoana-hloko ka bophara.