Lebitso:γ- aminobutyric acid()GABA)

Nomoro ea CAS:56-12-2

Mantsoe a tšoanang: 4-Aasiti ea minobutyric; asiti ea ammonia butyric;Asiti ea pipecolic.

1. Tšusumetso ea GABA ho fepeng liphoofolo e hloka ho ba e sa fetoheng ka nako e itseng. Ho ja lijo ho amana haufi-ufi le ts'ebetso ea tlhahiso ea liphoofolo le likhoho. E le mosebetsi o rarahaneng oa boitšoaro, ho fepa ho laoloa haholo ke tsamaiso ea methapo e bohareng. Setsi sa khora (nucleus ea ventromedial ea hypothalamus) le setsi sa ho fepa (sebaka sa hypothalamus se ka thoko) ke balaoli ba liphoofolo.

Setsi sa motheo sa lijo tsa GABA se ka susumetsa ho fepa liphoofolo ka ho thibela ts'ebetso ea setsi sa khoriso, ho ntlafatsa bokhoni ba ho fepa liphoofolo. Lithuto tse ngata li bontšitse hore ho kenya tekanyo e itseng ea GABA libakeng tse fapaneng tsa boko ba liphoofolo ho ka khothaletsa ho fepa liphoofolo haholo 'me ho ba le phello e itšetlehileng ka tekanyo. Ho eketsa GABA lijong tsa motheo tsa likolobe tse nontšang ho ka eketsa haholo ho ja lijo tsa likolobe, ho eketsa boima ba 'mele,' me ha ho fokotse tšebeliso ea protheine ea lijo.

2. Tšusumetso ea GABA ho tšilo ea lijo le tsamaiso ea Endocrine. Jwalo ka neurotransmitter kapa modulator, GABA e bapala karolo e pharaletseng tsamaisong ea methapo ea kutlo ea Autonomic ea liphoofolo tse nang le lesapo la mokokotlo.

3. Tšusumetso ea GABA ho motility ea mala. GABA e teng haholo tseleng ea mala, 'me likhoele tsa methapo tse sebetsang tsa GABA kapa lisele tse ntle tsa methapo li teng tsamaisong ea methapo le lera la tsela ea mala ea mammalian, lisele tsa endocrine tsa GABA le tsona li ajoa ka har'a epithelium ea mucosa ea mala. GABA e na le phello ea taolo liseleng tsa mesifa e boreleli ea mala, lisele tsa endocrine le lisele tse seng tsa endocrine. GABA ea kantle e na le phello e kholo ea thibelo likarolong tse arohaneng tsa mala tsa likhoto, e bonahatsoang ka phokotso ea amplitude ea ho phomola le ho honyela ha likarolo tse arohaneng tsa mala. Mokhoa ona oa thibelo oa GABA o ka 'na oa etsoa ka ho thibela litsamaiso tsa cholinergic le/kapa tse seng tsa cholinergic tsa mala, tse sebetsang ntle le tsamaiso ea adrenergic; E ka boela ea ikopanya ka boikemelo le receptor ea GABA e tsamaellanang liseleng tsa mesifa e boreleli ea mala.

4. GABA e laola metabolism ea liphoofolo. GABA e ka ba le litlamorao tse fapaneng tsamaisong ea tšilo ea lijo e le hormone ea lehae, joalo ka litšoelesa tse itseng le lihormone tsa endocrine. Tlas'a maemo a in vitro, GABA e ka susumetsa tlhahiso ea hormone ea kholo ka ho kenya tšebetsong receptor ea GABA ka mpeng. Hormone ea kholo ea liphoofolo e ka khothaletsa tlhahiso ea li-peptide tse ling sebeteng (joalo ka IGF-1), ea eketsa sekhahla sa metabolism ea lisele tsa mesifa, ea eketsa sekhahla sa kholo le sekhahla sa phetoho ea lijo tsa liphoofolo, Ka nako e ts'oanang, e boetse e fetotse kabo ea limatlafatsi tsa lijo 'meleng oa phoofolo; Ho ka nahanoa hore phello ea GABA e khothalletsang kholo e ka amana le taolo ea eona ea ts'ebetso ea hormone ea kholo ka ho ama ts'ebetso ea sistimi ea Endocrine ea methapo.