Tributyrin (TB)leMonolaurin (GML), e le di-additi tse sebetsang tsa phepo, di na le ditlamorao tse ngata tsa mmele temong ya dikgoho tse nang le lera, di ntlafatsa haholo tshebetso ya tlhahiso ya mahe, boleng ba mahe, bophelo bo botle ba mala, le metabolism ya mafura. Mesebetsi le mekgwa ya tsona ya mantlha ke ena:

1. Ntlafatsa tshebetso ya tlhahiso ya mahe
Glycerol Monolaurate(GML)

Ho eketsa 0.15-0.45g/kg GML lijong tsa likhoho tse behelang ho ka eketsa sekhahla sa tlhahiso ea mahe haholo, ho fokotsa sekhahla sa phetoho ea lijo, le ho eketsa boima ba mahe bo tloaelehileng.
Phuputso e bonts'a hore 300-450mg/kg GML e ka ntlafatsa sekhahla sa tlhahiso ea mahe a likhoho tse behelang le ho fokotsa sekhahla sa mahe a nang le sekoli.

Tributyrin (TB) 

Tekong ea likhoho tsa nama ea khomo, 500mg/kg TB e ka liehisa phokotso ea sekhahla sa tlhahiso ea mahe mohatong oa morao oa ho behela mahe, ea ntlafatsa matla a khetla ea mahe, le ho fokotsa sekhahla sa ho qhotsa.
E kopantsoe leGML(joalo ka mokhoa o nang le patente) o ka eketsa nako ea tlhahiso ea mahe a maholo le ho ntlafatsa melemo ea moruo.

2. Ntlafatsa boleng ba lehe

Mosebetsi oa GML
Eketsa bolelele ba protheine, diyuniti tsa Haff (HU), mme o ntlafatse mmala wa yolk.
Fetola sebopeho sa asiti e mafura a lehe le lenyenyane, eketsa li-acid tse mafura tse ngata tse saturated (PUFA) le li-acid tse mafura tse ngata tse saturated (MUFA), 'me u fokotse bongata ba li-acid tse mafura tse ngata tse saturated (SFA).

Ka tekanyo ea 300mg/kg, GML e ekelitse thatafalo ea khetla ea mahe le palo ea protheine e tšoeu ea mahe haholo.

Mosebetsi oaTB

Eketsa matla a likhetla tsa mahe le ho fokotsa sekhahla sa ho robeha ha khetla (joalo ka ho fokotsa 58.62-75.86% litekong).

Ho kgothaletsa tlhahiso ya dijini tse amanang le ho kenngwa ha calcium ka popelong (jwalo ka CAPB-D28K, OC17) le ho ntlafatsa calcification ya khetla ya lehe.

3. Ho laola metabolism ea mafura le ts'ebetso ea antioxidant
Mosebetsi oa GML
Fokotsa triglycerides (TG) maling, k'holeseterole eohle (TC), le k'holeseterole e tlase ea lipoprotein (LDL-C), 'me u fokotse mafura a ka mpeng.
Ntlafatsa ts'ebetso ea serum superoxide dismutase (SOD) le glutathione peroxidase (GSH Px), fokotsa bongata ba malondialdehyde (MDA), le ho ntlafatsa bokhoni ba antioxidant.
Mosebetsi oaTB
Fokotsa tekanyo ea triglyceride sebeteng (10.2-34.23%) 'me u ntlafatse liphatsa tsa lefutso tse amanang le oxidation ea mafura (joalo ka CPT1).
Fokotsa maemo a alkaline phosphatase (AKP) le MDA ka hara serum, mme o eketse bokgoni bohle ba antioxidant (T-AOC).

4. Ntlafatsa bophelo bo botle ba mala
Mosebetsi oa GML
Eketsa bolelele ba villus le karolelano ea villus ho villus (V/C) ea jejunum ho ntlafatsa sebopeho sa mala.
Fokotsa lintho tse bakang ho ruruha (tse kang IL-1 β, TNF-α), eketsa lintho tse thibelang ho ruruha (tse kang IL-4, IL-10), 'me u ntlafatse ts'ebetso ea thibelo ea mala.
Ntlafatsa sebopeho sa cecal microbiota, fokotsa karolo ea Proteobacteria, 'me u khothaletse kholo ea libaktheria tse molemo tse kang Spirogyraceae.
Mosebetsi oa lefuba
Fetola boleng ba pH ba mala, kgothaletsa ho ata ha dibaktheria tse molemo (tse kang lactobacilli), mme o thibele dibaktheria tse kotsi.
Ho eketsa tlhahiso ea liphatsa tsa lefutso tsa tight junction (joalo ka Occludin, CLDN4) ho ntlafatsa botšepehi ba thibelo ea mala.

5. Tshusumetso ya taolo ya mmele wa ho itšireletsa mafung
Mosebetsi oa GML
Ntlafatsa index ea spleen le index ea thymus, ntlafatsa ts'ebetso ea 'mele ea ho itšireletsa mafung.
Fokotsa matšoao a ho ruruha maling a kang aspartate aminotransferase (AST) le alanine aminotransferase (ALT).
Mosebetsi oa lefuba
Fokotsa karabelo ea ho ruruha ha mala ka ho laola tsela ea Toll-like receptor (TLR2/4).

6. Phello ea ts'ebeliso e kopanetsoeng
Patlisiso ea litokelo tsa molao e bontšitse hore motsoako oa GML le TB (joalo ka 20-40 TB+15-30 GML) o ka ntlafatsa ka kopanelo sekhahla sa tlhahiso ea mahe a likhoho tse behelang (92.56% khahlano le 89.5%), oa fokotsa ho ruruha ha methapo ea mali, le ho lelefatsa nako ea tlhahiso ea mahe e phahameng.

Kakaretso:

Glycerol Monolaurate (GML)leTributyrin (TB)e na le ditlamorao tse tlatsetsang temong ya dikgoho:

GMLe shebane leho ntlafatsa boleng ba lehe, ho laola metabolism ea mafura le ts'ebetso ea antioxidant;
TBe shebane leho ntlafatsa bophelo bo botle ba mala le metabolism ea calcium;
Motsoako o kae sebelisa litlamorao tse kopanetsoeng, e ntlafatsa ka botlalo ts'ebetso ea tlhahiso le boleng ba lehe.