Na o batla tshebetso e ntlafaditsweng le tahlehelo e fokolang ya phepelo?

Kamora ho kgwesa, dikolobe tse nyane di feta nakong e thata. Kgatelelo ya maikutlo, ho ikamahanya le dijo tse tiileng, le mala a ntseng a hola. Hangata sena se lebisa mathateng a tshilo ya dijo le kgolo e liehang.

Asiti ea Benzoic + Glycerol Monolaurate Sehlahisoa sa rona se secha

Motsoako o bohlale oa benzoic acid le glycerol: metsoako e 'meli e tsebahalang e sebetsang hantle le ho feta hammoho.

1. Ntlafatso ea Kopanelo ea Litlamorao tsa Antibacterial
Asiti ea Benzoic:

• Haholo-holo e sebetsa libakeng tse nang le asiti (mohlala, tsela ea mala), e kenella lera la lisele tsa likokoana-hloko ka sebopeho sa eona sa limolek'hule tse sa arohaneng, e sitisa ts'ebetso ea li-enzyme, 'me e thibela kholo ea likokoana-hloko. E sebetsa haholo-holo khahlanong le hlobo, tomoso le libaktheria tse itseng.
• E fokotsa pH ka maleng, e thibela ho ata ha libaktheria tse kotsi (mohlala,E. coli,Salmonella).

Glycerol Monolaurate:

• Glycerol monolaurate, e tswang ho lauric acid, e bontsha tshebetso e matla ya ho lwantsha dikokwana-hloko. E sitisa lera la sele ya baktheria (haholoholo dibaktheria tse nang le Gram-positive) mme e thibela ho ata ha dikokwana-hloko (mohlala, kokoana-hloko ya letshollo ya lefu la porcine).
• E bontša litlamorao tse kholo tsa thibelo khahlanong le likokoana-hloko tsa mala (mohlala,Clostridium,Streptococcus) le li-fungus.

Litlamorao tsa ho sebelisana 'moho:

• Ketso ea ho Loantša Likokoana-hloko e Broad-Spectrum: Motsoako ona o akaretsa mefuta e mengata ea likokoana-hloko (libaktheria, li-fungus, livaerase), o fokotsa mojaro oa likokoana-hloko mala.
• Kotsi e Fokolitsoeng ea Khanyetso: Mekhoa e fapaneng ea ts'ebetso e fokotsa kotsi ea khanyetso e amanang le tšebeliso ea nako e telele ea setlolo se le seng.
• Ho Phela ha Liphoofolo tse Nyenyane ho Ntlafalitsoeng: Haholo-holo ho dikolobe tse nyane tse kgwesitsweng, motswako ona o thusa ho laola letshollo le ho ntlafatsa bophelo bo botle ba mala.

2. Khothaletso ea Bophelo bo Botle ba Mala le ho Monya ha Tšilo ea Lijo
Asiti ea Benzoic:

• E fokotsa pH ea mala, e kenya tšebetsong pepsinogen, 'me e ntlafatsa ho sileha ha protheine.
• E fokotsa dihlahiswa tse kotsi tsa metabolism tse kang ammonia le amine, e ntlafatsa tikoloho ya mala.

Glycerol Monolaurate:

• Jwalo ka sehlahiswa sa mafura a ketane e mahareng, e fana ka matla ka ho toba ho disele tsa epithelial tsa mala, e leng se kgothaletsang ntshetsopele ya villus.
• E ntlafatsa ts'ebetso ea thibelo ea mala le ho fokotsa ho fetisetsoa ha endotoxin.

Litlamorao tsa ho sebelisana 'moho:

• Mokhoa o Ntlafetseng oa ho Ikamahanya le Mala: Tšebeliso e kopaneng e eketsa karolelano ea botebo ba villus ho tloha bophahamong ho ea ho crypt, e leng se eketsang bokhoni ba ho monya limatlafatsi.
• Microbiota e Lekaneng: E ​​thibela likokoana-hloko ha e ntse e khothalletsa ho kolone ha libaktheria tse molemo tse kangLactobacillus.

3. Ntlafatso ea Ts'ebetso ea 'Mele oa ho Itšireletsa le Litlamorao tse Khahlanong le ho Futhumala
Asiti ea Benzoic:

• Ka tsela e sa tobang e fokotsa khatello ea 'mele ea ho itšireletsa mafung ka ho ntlafatsa tikoloho ea mala.

Glycerol Monolaurate:

• E fetola likarabo tsa 'mele oa ho itšireletsa mafung ka kotloloho, e thibela litsela tsa ho ruruha (mohlala, NF-κB), 'me e fokotsa ho ruruha ha mala.
• E eketsa sesole sa 'mele (mohlala, e eketsa tlhahiso ea sigA).

Litlamorao tsa ho sebelisana 'moho:

• Ho Fokotsa ho Ruruha ha Metsi: Ho fokotsa tlhahiso ea lintho tse bakang ho ruruha (mohlala, TNF-α, IL-6), ho ntlafatsa boemo ba bophelo bo botle bo sa lokelang liphoofolong.
• Mokhoa o Mong oa Lithibela-mafu: Lijong tse se nang lithibela-mafu, motsoako o ka nka sebaka sa li-promoter tsa kholo ea lithibela-mafu (AGPs) ka karolo e itseng.

4. Ntlafatso ea Tshebetso ea Tlhahiso le Melemo ea Moruo
Mekhoa e Tloaelehileng:

• Ka mekhoa e boletsoeng ka holimo, e ntlafatsa sekhahla sa phetoho ea lijo, e fokotsa ho ata ha mafu, 'me e eketsa keketseho ea boima ba' mele letsatsi le letsatsi, tlhahiso ea mahe, kapa chai ea lebese.
• Tšusumetso ea ho eketsa asiti ea benzoic acid le phepelo ea matla e tsoang ho glycerol monolaurate li ntlafatsa ka tsela e ts'oanang katleho ea metabolism.

Libaka tsa Kopo:

• Temo ea Likolobe: Haholo-holo nakong ea ho khoesa ha likolobe, ho fokotsa khatello ea maikutlo le ho ntlafatsa sekhahla sa ho phela.
• Likhoho: E ntlafatsa sekhahla sa kholo ho li-broiler le boleng ba khetla ea mahe ka ho aroloa.
• Li-buminant: E fetola ho belisoa ha rumen le ho ntlafatsa peresente ea mafura a lebese.

5. Litlhokomelo tsa Polokeho le Tšebeliso
Polokeho: Ka bobedi di tsejwa e le di-additives tse bolokehileng tsa phepo (benzoic acid e bolokehile maemong a loketseng; glycerol monolaurate ke lipid derivative ya tlhaho), ka dikotsi tse tlase tse setseng.

Litlhahiso tsa Tlhahiso:

• Hangata e kopantsoe le lintho tse ling tse kang li-organic acid, li-prebiotic le li-enzyme ho ntlafatsa katleho ea kakaretso.
• Tekanyo e lokela ho laolwa ka hloko (maemo a kgothaletswang: benzoic acid 0.5–1.5%, glycerol monolaurate 0.05–0.2%). Bongata bo feteletseng bo ka ama monate kapa ba sitisa ho leka-lekana ha microbiota ya mala.

Litlhoko tsa Ts'ebetso: Netefatsa hore motsoako o tsoakane ka tsela e ts'oanang ho qoba ho kopana kapa ho senyeha.

Kakaretso
Asiti ea Benzoic le glycerol monolaurate li sebetsa hammoho lijong tse ling ka litsela tse ngata, ho kenyeletsoa le tšebelisano-'moho ea likokoana-hloko, tšireletso ea mala, phetoho ea 'mele ea ho itšireletsa mafung le ntlafatso ea metabolism, ho ntlafatsa ts'ebetso ea tlhahiso ea liphoofolo le bophelo bo botle. Motsoako oa tsona o tsamaisana le mokhoa oa "temo e se nang lithibela-mafu" 'me o emela leano le sebetsang la ho nkela sebaka ka karolo e itseng ea ba khothalletsang kholo ea lithibela-mafu..Litšebelisong tse sebetsang, karolelano e lokela ho ntlafatsoa ho latela mefuta ea liphoofolo, mohato oa kholo le boemo ba bophelo bo botle ho fihlela melemo e metle.